Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease.

ABSTRACT:

Background

The cholinergic system plays a key role in cognitive impairment in Parkinson's disease (PD). Previous acetylcholinesterase positron emission tomography imaging studies found memory, attention, and executive function correlates of global cortical cholinergic losses. Vesicular acetylcholine transporter positron emission tomography allows for more accurate topographic assessment of not only cortical but also subcortical cholinergic changes.

Objective

The objectiveof this study was to investigate the topographic relationship between cognitive functioning and regional cholinergic innervation in patients with PD.

Methods

A total of 86 nondemented patients with PD (mean ± SD age 67.8 ± 7.6 years, motor disease duration 5.8 ± 4.6 years), and 12 healthy control part

SUBMITTER: van der Zee S 

PROVIDER: S-EPMC7988481 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature