Genetic And Morphological Evaluation (GAME) score for patients with colorectal liver metastases.

ABSTRACT:

Background

This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS.

Methods

A cohort of patients who underwent resection for CRLM at the Johns Hopkins Hospital (JHH) was analysed to identify independent predictors of overall survival (OS) that can be assessed before operation; these factors were combined into the Genetic And Morphological Evaluation (GAME) score. The score was compared with the current standard (Fong score) and validated in an external cohort of patients from the Memorial Sloan Kettering Cancer Center (MSKCC).

Results

Six preoperative predictors of worse OS were identified on multivariable Cox regression analysis

SUBMITTER: Margonis GA 

PROVIDER: S-EPMC7988484 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature