BMPR2 expression level is correlated with low immune infiltration and predicts metastasis and poor survival in osteosarcoma.

ABSTRACT: Osteosarcoma is the most common malignant bone tumor in adolescents and young adults, and identifying biomarkers for prognosis and therapy is necessary. Bone morphogenetic protein receptor 2 (BMPR2) is involved in various cellular functions, including cell adhesion, proliferation and invasion, inflammation, apoptosis and metastatic spread. However, the correlation between BMPR2 expression levels and prognosis and tumor-infiltrating immune cells in osteosarcoma is not well understood. In the present study, the expression level of BMPR2 was investigated using the Oncomine and R2 databases. The association between the expression level of BMPR2 and the clinical prognosis of patients with cancer was analyzed using the R2 database. The relationship between the expression level of BMPR2 and immun

SUBMITTER: Cao H 

PROVIDER: S-EPMC7988701 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature