Ontology highlight
ABSTRACT:
SUBMITTER: Zheng H
PROVIDER: S-EPMC7988739 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Zheng Hong H Rao Aditya M AM Dermadi Denis D Toh Jiaying J Murphy Jones Lara L Donato Michele M Liu Yiran Y Su Yapeng Y Dai Cheng L CL Kornilov Sergey A SA Karagiannis Minas M Marantos Theodoros T Hasin-Brumshtein Yehudit Y He Yudong D YD Giamarellos-Bourboulis Evangelos J EJ Heath James R JR Khatri Purvesh P
Immunity 20210324 4
Viral infections induce a conserved host response distinct from bacterial infections. We hypothesized that the conserved response is associated with disease severity and is distinct between patients with different outcomes. To test this, we integrated 4,780 blood transcriptome profiles from patients aged 0 to 90 years infected with one of 16 viruses, including SARS-CoV-2, Ebola, chikungunya, and influenza, across 34 cohorts from 18 countries, and single-cell RNA sequencing profiles of 702,970 im ...[more]