Mavacamten preserves length-dependent contractility and improves diastolic function in human engineered heart tissue.

ABSTRACT: Comprehensive functional characterization of cardiac tissue includes investigation of length and load dependence. Such measurements have been slow to develop in engineered heart tissues (EHTs), whose mechanical characterizations have been limited primarily to isometric and near-isometric behaviors. A more realistic assessment of myocardial function would include force-velocity curves to characterize power output and force-length loops mimicking the cardiac cycle to characterize work output. We developed a system that produces force-velocity curves and work loops in human EHTs using an adaptive iterative control scheme. We used human EHTs in this system to perform a detailed characterization of the cardiac β-myosin specific inhibitor, mavacamten. Consistent with the clinically proposed appl

SUBMITTER: Sewanan LR 

PROVIDER: S-EPMC7988756 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature