Separating insulin-mediated and non-insulin-mediated glucose uptake during and after aerobic exercise in type 1 diabetes.

ABSTRACT: Aerobic exercise in type 1 diabetes (T1D) causes rapid increase in glucose utilization due to muscle work during exercise, followed by increased insulin sensitivity after exercise. Better understanding of these changes is necessary for models of exercise in T1D. Twenty-six individuals with T1D underwent three sessions at three insulin rates (100%, 150%, 300% of basal). After 3-h run-in, participants performed 45 min aerobic exercise (moderate or intense). We determined area under the curve for endogenous glucose production (AUC_EGP) and rate of glucose disappearance (AUC_Rd) over 45 min from exercise start. A novel application of linear regression of R_d across the three insulin sessions allowed separation of insulin-mediated from non-insulin-mediated glucose

SUBMITTER: Nguyen TP 

PROVIDER: S-EPMC7988786 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature