Drug Treatment of Neuromyelitis Optica Spectrum Disorders: Out with the Old, in with the New?

ABSTRACT:

Introduction

Neuromyelitis optica spectrum disorders (NMOSD) are rare neuroinflammatory demyelinating diseases of the CNS, mainly affecting optic nerves, spinal cord and brainstem regions. The diagnosis depends on clinical symptoms, MRI findings and the detection of autoantibodies against the water channel aquaporin 4 (AQP4-Ab). This autoantibody is particularly important for diagnostic sensitivity and specificity and further sets the course for major therapeutic decisions. Due to a relapsing course with the accumulation of disability, relapse prevention by immunotherapy is crucial in NMOSD. Until recently, disease-modifying agents specific to NMOSD were not available, and patients were treated with various immunosuppressive drugs and regimens - with variable success. Fortunately,

SUBMITTER: Held F 

PROVIDER: S-EPMC7989551 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature