Perspectives on plant flavonoid quercetin-based drugs for novel SARS-CoV-2.

ABSTRACT:

Background

The world pandemic COVID-19 caused by SARS-CoV-2 is currently claiming thousands of lives. Flavonoids abundantly present in the fruits and vegetables, especially quercetin, are shown to have antiviral activities.

Main text

This paper reviews the capability of the plant flavonoid quercetin to fight the novel coronavirus and the possibility for drug development based on this. The mode of action explaining the known pathways through which this molecule succeeds in the antiviral activity, action of quercetin on SARS-CoV-2 main protease 3CL^pro, antiviral activities of its derivatives on human viruses, effect of combination of zinc co-factor along with quercetin in the COVID-19 treatment, and the regulation of miRNA genes involved in the viral pathogenesis ar

SUBMITTER: Saakre M 

PROVIDER: S-EPMC7989718 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature