Functional changes in beta cells during ageing and senescence.

ABSTRACT: Insulin secretion from beta cells is crucial for maintaining euglycaemia and preventing type 2 diabetes, a disease correlated with ageing. Therefore, understanding the functional changes that beta cell function undergoes with age can reveal new therapeutic targets and strategies to delay or revert the disease. Herein, a systematic review of the literature agrees that, as humans age, their beta cell function declines, independently of peripheral insulin resistance, BMI and waist circumference. Rodent studies reveal that, with age, basal insulin secretion increases with either no change or an increase in stimulated insulin secretion, but the biological significance of this is unclear. The accumulation of senescent beta cells could explain some of these functional changes: transcriptional ana

SUBMITTER: Aguayo-Mazzucato C 

PROVIDER: S-EPMC7990033 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature