Cell-substrate mechanics guide collective cell migration through intercellular adhesion: a dynamic finite element cellular model.

ABSTRACT: During the process of tissue formation and regeneration, cells migrate collectively while remaining connected through intercellular adhesions. However, the roles of cell-substrate and cell-cell mechanical interactions in regulating collective cell migration are still unclear. In this study, we employ a newly developed finite element cellular model to study collective cell migration by exploring the effects of mechanical feedback between cell and substrate and mechanical signal transmission between adjacent cells. Our viscoelastic model of cells consists many triangular elements and is of high resolution. Cadherin adhesion between cells is modeled explicitly as linear springs at subcellular level. In addition, we incorporate a mechano-chemical feedback loop between cell-substrate mechanics

SUBMITTER: Zhao J 

PROVIDER: S-EPMC7990038 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature