Identification of PSMD7 as a prognostic factor correlated with immune infiltration in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Recurrent locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) is associated with dismal prognosis because of its highly invasive behavior and resistance to conventional intensive chemotherapy. The identification of effective markers for early diagnosis and prognosis is important for reducing mortality and ensuring that therapy for HNSCC is effective. Proteasome 26S subunit, non-ATPase 7 (PSMD7) is an ATP-independent component of the 19S regulatory subunit. The prognostic value of PSMD7 and the association with immune infiltration in HNSCC remains unclear.

Methods

The Sangerbox, Oncomine, UALCAN and Human Protein Atlas (HPA) databases were used to examine PSMD7 expression profiles in HNSCC. The CVCDAP was used to analysis the association of

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7990087 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature