The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia.

ABSTRACT: Osteoporosis and its precursor osteopenia are common metabolic bone diseases in postmenopausal women. A growing body of evidence suggests that the gut microbiota is involved in the regulation of bone metabolism; however, there are few studies examining how gut microbiomes in osteoporosis and osteopenia may differ from those in healthy individuals. The aim of this study was to characterize the diversity, composition, and functional gene potential of the gut microbiota of healthy, osteopenic, and osteoporotic women. Body composition, bone density, and fecal metagenomes were analyzed in 86 postmenopausal women. The women were classified as healthy, osteopenic, or osteoporotic based on T-scores. The taxonomic and functional gene compositions of the microbiome were analyzed using shotgun

SUBMITTER: Rettedal EA 

PROVIDER: S-EPMC7990138 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature