Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.

ABSTRACT: Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age-related disease and improve the quality of life. In this study, several interventions associated with lifespan extension in invertebrates or improvement of age-related disease were tested in mouse models to determine if they were effective in slowing tissue aging in a broad spectrum of functional assays. Benzoxazole, which extends the lifespan of Caenorhabditis elegans, slowed age-related femoral bone loss in mice. Rates of change were established for clinically significant parameters in untreated mice, including kyphosis, blood glucose, body composition, activity, metabolic measures, and detailed parameters of skel

SUBMITTER: Evans DS 

PROVIDER: S-EPMC7990142 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature