Dataset Information

Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.

ABSTRACT: Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age-related disease and improve the quality of life. In this study, several interventions associated with lifespan extension in invertebrates or improvement of age-related disease were tested in mouse models to determine if they were effective in slowing tissue aging in a broad spectrum of functional assays. Benzoxazole, which extends the lifespan of Caenorhabditis elegans, slowed age-related femoral bone loss in mice. Rates of change were established for clinically significant parameters in untreated mice, including kyphosis, blood glucose, body composition, activity, metabolic measures, and detailed parameters of skeletal aging in bone. These findings have implications for the study of preclinical physiological aging and therapies targeting aging. Finally, an online application was created that includes the calculated rates of change and that enables power and variance to be calculated for many clinically important metrics of aging with an emphasis on bone. This resource will help in future study designs employing novel interventions in aging mice. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.

SUBMITTER: Evans DS

PROVIDER: S-EPMC7990142 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.

Evans Daniel S DS O'Leary Monique N MN Murphy Ryan R Schmidt Minna M Koenig Kristin K Presley Michael M Garrett Brittany B Kim Ha-Neui HN Han Li L Academia Emmeline C EC Laye Matt J MJ Edgar Daniel D Zambataro Christopher A CA Barhydt Tracey T Dewey Colleen M CM Mayfield Jarrott J Wilson Joy J Alavez Silvestre S Lucanic Mark M Kennedy Brian K BK Almeida Maria M Andersen Julie K JK Kapahi Pankaj P Lithgow Gordon J GJ Melov Simon S

JBMR plus 20210216 3

Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age-related disease and improve the quality of life. In this study, several interventions associated with lifespan extension in invertebrates or improvement of age-related disease were tested in mouse models to determine if they were effective in slowing tissue aging in a broad spectrum of functional assays. Benzoxazole, which exten ...[more]

PMID: 33778327

Similar Datasets

Project description:BackgroundEvidence has begun to emerge indicating that cancer survivors experience accelerated aging. This study examines this phenomenon by evaluating trajectories of functional decline in older adults with a history of a cancer diagnosis relative to those without a history of cancer.MethodsCommunity dwelling healthy volunteers in the Baltimore Longitudinal Study of Aging were evaluated in the Clinical Research Unit of the National Institute on Aging Intramural Research Program. Between 2006 and 2019, 1728 men and women (aged 22-100) underwent clinical evaluation of functional status; 359 reported having a history of cancer. Longitudinal associations between self-reported cancer history and measures of functional decline were examined using generalized estimating equations. Additionally, time-to-event and Cox proportional hazards models were used to examine trajectories of decline. Where appropriate, age-stratified associations were examined, and models were adjusted for sex, body mass index, race, smoking status, education, and number of comorbid conditions.ResultsAmong all participants, a history of cancer was associated with 1.42 (95% CI 1.11-1.81) greater odds of weak grip strength. Among older participants (>65 years of age), those with a history of cancer had 1.61 (95% CI 1.28, 2.02) greater odds of slow gait speed and a 0.11 unit (95% CI 0.19-0.03) lower physical performance score than those with no cancer history. Time-to-event analysis showed that older individuals with a history of cancer experienced steeper decline in grip strength and gait speed than older adults with no history of cancer (p < 0.01).ConclusionCancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories. Observational and intervention studies are needed for prevention, mitigation, and/or reversal of aging-related effects of cancer and its treatment.

Dataset Information

Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.

Publications

Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets