Assessing the contribution of tumor mutational phenotypes to cancer progression risk.

ABSTRACT: Cancer occurs via an accumulation of somatic genomic alterations in a process of clonal evolution. There has been intensive study of potential causal mutations driving cancer development and progression. However, much recent evidence suggests that tumor evolution is normally driven by a variety of mechanisms of somatic hypermutability, which act in different combinations or degrees in different cancers. These variations in mutability phenotypes are predictive of progression outcomes independent of the specific mutations they have produced to date. Here we explore the question of how and to what degree these differences in mutational phenotypes act in a cancer to predict its future progression. We develop a computational paradigm using evolutionary tree inference (tumor phylogeny) algorithm

SUBMITTER: Tao Y 

PROVIDER: S-EPMC7990181 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature