Elucidating the immune infiltration in acne and its comparison with rosacea by integrated bioinformatics analysis.

ABSTRACT:

Background

Acne vulgaris and rosacea are common inflammatory complications of the skin, both characterized by abnormal infiltration of immune cells. The two diseases can be differentiated based on characteristic profile of the immune cell infiltrates at the periphery of disease lesions. In addition, dysregulated infiltration of immune cells not only occur in the acne lesions but also in non-lesional areas of patients with the disease, thus characterizing the immune infiltration in these sites can further enhance our understanding on the pathogenesis of acne.

Methods

Five microarray data-sets (GSE108110, GSE53795, GSE65914, GSE14905 and GSE78097) were downloaded from Gene Expression Omnibus. After removing the batch effects and normalizing the data, we applied the CIBERSORT a

SUBMITTER: Yang L 

PROVIDER: S-EPMC7990205 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature