Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study.

ABSTRACT:

Objectives

Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. We hypothesized that colchicine, by counteracting proinflammatory pathways implicated in the uncontrolled inflammatory response of COVID-19 patients, reduces pulmonary complications, and improves survival.

Methods

This retrospective study included 71 consecutive COVID-19 patients (hospitalized with pneumonia on CT scan or outpatients) who received colchicine and compared with 70 control patients who did not receive colchicine in two serial time periods at the same institution. We used inverse probability of treatment propensity-score weighting to examine differences in mortality, clinical improvement (using a 7-point ordinary scale), and inflammatory markers between the two groups.

SUBMITTER: Manenti L 

PROVIDER: S-EPMC7990208 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature