Electrochemical C(sp³)-H Fluorination.

ABSTRACT: A simple and robust method for electrochemical alkyl C-H fluorination is presented. Using a simple nitrate additive, a widely available fluorine source (Selectfluor), and carbon-based electrodes, a wide variety of activated and unactivated C-H bonds were converted to their C-F congeners. The scalability of the reaction was also demonstrated with a 100 gram preparation of fluorovaline.

SUBMITTER: Takahira Y 

PROVIDER: S-EPMC7990259 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature