A Protocol for the Generation of Treatment-naive Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models.

ABSTRACT: Diffuse intrinsic pontine glioma (DIPG) is a universally fatal tumor of the brainstem, most commonly affecting young children. Due to its location, surgical resection is not achievable, but consideration of a biopsy has become standard practice at children's hospitals with the appropriate neurosurgical expertise. While the decision to obtain a biopsy should be directed by the presence of atypical radiographic features that call the diagnosis of DIPG into question or the requirement of biopsy tissue for clinical trial enrollment, once this precious tissue is available its use for research should be considered. The majority of DIPG and diffuse midline glioma, H3 K27M-mutant (DMG) models are autopsy-derived or genetically-engineered, each of which has limitations for translational studies, so

SUBMITTER: Biery MC 

PROVIDER: S-EPMC7990285 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature