Planning deficits in Huntington's disease: A brain structural correlation by voxel-based morphometry.

ABSTRACT:

Introduction

Early Huntington's disease (HD) patients begin to show planning deficits even before motor alterations start to manifest. Generally, planning ability is associated with the functioning of anterior brain areas such as the medial prefrontal cortex. However, early HD neuropathology involves significant atrophy in the occipital and parietal cortex, suggesting that more posterior regions could also be involved in these planning deficits.

Objective

To identify brain regions associated with planning deficits in HD patients at an early clinical stage.

Materials and methods

Twenty-two HD-subjects genetically confirmed with incipient clinical manifestation and twenty healthy subjects were recruited. All participants underwent MRI T1 image acquisition as well as tes

SUBMITTER: Calderon-Villalon J 

PROVIDER: S-EPMC7990304 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature