Amending microbiota by targeting intestinal inflammation with TNF blockade attenuates development of colorectal cancer.

ABSTRACT: Intestinal inflammation and microbiota are two important components of colorectal cancer (CRC) etiology. However, it is not clear how tuning inflammation using clinically relevant anti-inflammatory treatment impacts microbiota or whether this consequently influences CRC outcome. Here, using chemically induced (DSS/Apc ^min/+) and spontaneous (Apc ^min/+ ;Il10 ^-/-) mouse CRC models colonized by colibactin-producing Escherichia coli, we established the role of microbiota in mediating the antitumorigenic effect of anti-tumor necrosis factor (TNF) therapy. We found that TNF blockade attenuated colitis and CRC development. Microbiota community structure and gene activities significantly changed with disease development, which was preven

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7990316 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature