Clinical and Biological Features of Neuroendocrine Prostate Cancer.

ABSTRACT:

Purpose of review

Neuroendocrine prostate cancer (NEPC) is an aggressive histologic subtype of prostate cancer that most commonly arises in later stages of prostate cancer as a mechanism of treatment resistance. The poor prognosis of NEPC is attributed in part to late diagnosis and a lack of effective therapeutic agents. Here, we review the clinical and molecular features of NEPC based on recent studies and outline future strategies and directions.

Recent findings

NEPC can arise "de novo" but most commonly develops as a result of lineage plasticity whereby prostate cancer cells adopt alternative lineage programs as a means to bypass therapy. Dependence on androgen receptor (AR) signaling is lost as tumors progress from a prostate adenocarcinoma to a NEPC histology, typically

SUBMITTER: Yamada Y 

PROVIDER: S-EPMC7990389 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature