Life Course Air Pollution Exposure and Cognitive Decline: Modelled Historical Air Pollution Data and the Lothian Birth Cohort 1936.

ABSTRACT:

Background

Air pollution has been consistently linked with dementia and cognitive decline. However, it is unclear whether risk is accumulated through long-term exposure or whether there are sensitive/critical periods. A key barrier to clarifying this relationship is the dearth of historical air pollution data.

Objective

To demonstrate the feasibility of modelling historical air pollution data and using them in epidemiologicalmodels.

Methods

Using the EMEP4UK atmospheric chemistry transport model, we modelled historical fine particulate matter (PM2.5) concentrations for the years 1935, 1950, 1970, 1980, and 1990 and combined these with contemporary modelled data from 2001 to estimate life course exposure in 572 participants in the Lothian Birth Cohort 1936 with lifetim

SUBMITTER: Russ TC 

PROVIDER: S-EPMC7990442 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature