Stored RBC metabolism as a function of caffeine levels.

ABSTRACT:

Background

Coffee consumption is extremely common in the United States. Coffee is rich with caffeine, a psychoactive, purinergic antagonist of adenosine receptors, which regulate red blood cell energy and redox metabolism. Since red blood cell (purine) metabolism is a critical component to the red cell storage lesion, here we set out to investigate whether caffeine levels correlated with alterations of energy and redox metabolism in stored red blood cells.

Study design and methods

We measured the levels of caffeine and its main metabolites in 599 samples from the REDS-III RBC-Omics (Recipient Epidemiology Donor Evaluation Study III Red Blood Cell-Omics) study via ultra-high-pressure-liquid chromatography coupled to high-resolution mass spectrometry and correlated them to glo

SUBMITTER: D'Alessandro A 

PROVIDER: S-EPMC7990510 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature