Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

ABSTRACT: Regulatory T (T_reg) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the recruitment, differentiation and activity of these cells^1,2. Tumour cells show deregulated metabolism, leading to a metabolite-depleted, hypoxic and acidic TME³, which places infiltrating effector T cells in competition with the tumour for metabolites and impairs their function^4-6. At the same time, T_reg cells maintain a strong suppression of effector T cells within the TME^7,8. As previous studies suggested that T_reg cells possess a distinct metabolic profile from effector T cells^9-11, we hypothesized that the altered metabolic landsc

SUBMITTER: Watson MJ 

PROVIDER: S-EPMC7990682 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature