Fasting-induced FOXO4 blunts human CD4⁺ T helper cell responsiveness.

ABSTRACT: Intermittent fasting blunts inflammation in asthma¹ and rheumatoid arthritis², suggesting that fasting may be exploited as an immune-modulatory intervention. However, the mechanisms underpinning the anti-inflammatory effects of fasting are poorly characterized^3-5. Here, we show that fasting in humans is sufficient to blunt CD4⁺ T helper cell responsiveness. RNA sequencing and flow cytometry immunophenotyping of peripheral blood mononuclear cells from volunteers subjected to overnight or 24-h fasting and 3 h of refeeding suggest that fasting blunts CD4⁺ T helper cell activation and differentiation. Transcriptomic analysis reveals that longer fasting has a more robust effect on CD4⁺ T-cell biology. Through bioinformatics analy

SUBMITTER: Han K 

PROVIDER: S-EPMC7990708 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature