Immune Profiling Reveals Molecular Classification and Characteristic in Urothelial Bladder Cancer.

ABSTRACT: Urothelial bladder cancer (UBC) is the most common malignant tumor of the urinary system. Most patients do not benefit from treatment with immune checkpoint inhibitors, which are closely associated with immune profiling in the context of UBC. Therefore, we aimed to characterize the immune profile of UBC to identify different immune subtypes that may influence therapy choice. We identified four subtypes of UBC based on immune profiling including immune ignorant, cold tumor, immune inactive, and hot tumor. After excluding the cold tumor subtype because of its unique pathology distinct from the other types, a high correlation between patient survival and immune characteristics was observed. Most immune cell types had highly infiltrated the hot tumor subtype compared to other subtypes. Interes

SUBMITTER: Yang L 

PROVIDER: S-EPMC7990773 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature