The course of multiple sclerosis rewritten: a Norwegian population-based study on disease demographics and progression.

ABSTRACT:

Objectives

Over the past few decades, there has been an improvement in the rate of disability progression in multiple sclerosis (MS) patients, and most studies relate this evolvement to the introduction of disease-modifying therapies. However, several other factors have changed over this period, including access to MRI and newer diagnostic criteria. The aim of this study is to investigate changes in the natural course of MS over time in a near-complete and geographically well-defined population from the south-east of Norway.

Methods

We examined disease progression and demographics over two decades and assessed the effect of disease-modifying therapies using linear mixed-effect models.

Results

In a cohort of 2097 patients, we found a significant improvement in disabili

SUBMITTER: Simonsen CS 

PROVIDER: S-EPMC7990804 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature