Cognitive impairments are independently associated with shorter survival in diffuse glioma patients.

ABSTRACT:

Background

Diffuse gliomas (WHO grade II-IV) are progressive primary brain tumors with great variability in prognosis. Cognitive deficits are of important prognostic value for survival in diffuse gliomas. Until now, few studies focused on domain-specific neuropsychological assessment and rather used MMSE as a measure for cognitive functioning. Additionally, these studies did not take WHO 2016 diagnosis into account. We performed a retrospective cohort study with the aim to investigate the independent relationship between cognitive functioning and survival in treatment-naive patients undergoing awake surgery for a diffuse glioma.

Methods

In patients undergoing awake craniotomy between 2010 and 2017, we performed pre-operative neuropsychological assessments in five cognitive d

SUBMITTER: van Kessel E 

PROVIDER: S-EPMC7990824 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature