Prognosis and Genomic Landscape of Liver Metastasis in Patients With Breast Cancer.

ABSTRACT:

Objective

The prognosis of breast cancer liver metastasis (BCLM) is poor, and its molecular mechanism is unclear. We aimed to determine the factors that affect the prognosis of patients with BCLM and investigate the genomic landscape of liver metastasis (LM).

Methods

We described the prognosis of patients with BCLM and focused on prognosis prediction for these patients based on clinicopathological factors. Nomogram models were constructed for progression-free survival (PFS) and overall survival (OS) by using a cohort of 231 patients with BCLM who underwent treatment at Shandong Cancer Hospital and Institute (SCHI). We explored the molecular mechanism of LM and constructed driver genes, mutation signatures by using a targeted sequencing dataset of 217 samples of LM and 479 un

SUBMITTER: Tian C 

PROVIDER: S-EPMC7991092 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature