Thrombolysis Combined Therapy Using CuS@SiO₂-PEG/uPA Nanoparticles.

ABSTRACT: Massive hemorrhage caused by the uncontrolled release of thrombolysis drugs is a key issue of thrombolysis therapy in clinical practice. In this study, we report a near-infrared (NIR) light-triggered drug delivery system, i.e., CuS@mSiO₂-PEG (CSP) nanoparticles, for the loading of a thrombolytic drug (urokinase plasminogen activators, uPA). CSP nanoparticles with the CuS nanoparticles as photothermal agents and mesoporous SiO₂ for the loading of uPA were synthesized using a facile hydrothermal method. The CSP core-shell nanoparticles were demonstrated to possess excellent photothermal performance, exhibiting a photothermal conversion efficiency of up to 52.8%. Due to the mesoporous SiO₂ coating, the CSP core-shell nanoparticles exhibited appropriate pore si

SUBMITTER: Fu D 

PROVIDER: S-EPMC7991581 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature