Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort.

ABSTRACT:

Rationale

There are no validated measures of disease activity in COPD. Since "active" disease is expected to have worse outcomes (e.g. mortality), we explored potential markers of disease activity in patients enrolled in the ECLIPSE cohort in relation to 8-year all-cause mortality.

Methods

We investigated 1) how changes in relevant clinical variables over time (1 or 3 years) relate to 8-year mortality; 2) whether these variables inter-relate; and 3) if any clinical, imaging and/or biological marker measured cross-sectionally at baseline relates to any activity component.

Results

Results showed that 1) after 1 year, hospitalisation for COPD, exacerbation frequency, worsening of body mass index, airflow obstruction, dyspnoea and exercise (BODE) index or health st

SUBMITTER: Celli B 

PROVIDER: S-EPMC7991608 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature