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Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan.


ABSTRACT: Polio or poliomyelitis is a disabling and life-threatening disease caused by poliovirus (PV). As a consequence of global polio vaccination efforts, wild PV serotypes 2 and 3 have been eradicated around the world, and wild PV serotype 1-transmitted cases have been largely eliminated except for limited regions. However, vaccine-derived PV, pathogenically reverted live PV vaccine strains, has become a serious issue. For the global eradication of polio, the World Health Organization is conducting the third edition of the Global Action Plan, which is requesting stringent control of potentially PV-infected materials. To facilitate the mission, we generated a PV-nonsusceptible Vero cell subline, which may serve as an ideal replacement of standard Vero cells to isolate emerging/re-emerging viruses without the risk of generating PV-infected materials.

SUBMITTER: Okemoto-Nakamura Y 

PROVIDER: S-EPMC7991635 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan.

Okemoto-Nakamura Yuko Y   Someya Kenji K   Yamaji Toshiyuki T   Saito Kyoko K   Takeda Makoto M   Hanada Kentaro K  

Scientific reports 20210324 1


Polio or poliomyelitis is a disabling and life-threatening disease caused by poliovirus (PV). As a consequence of global polio vaccination efforts, wild PV serotypes 2 and 3 have been eradicated around the world, and wild PV serotype 1-transmitted cases have been largely eliminated except for limited regions. However, vaccine-derived PV, pathogenically reverted live PV vaccine strains, has become a serious issue. For the global eradication of polio, the World Health Organization is conducting th  ...[more]

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