Genetic comorbidity between major depression and cardio-metabolic traits, stratified by age at onset of major depression.

ABSTRACT: It is imperative to understand the specific and shared etiologies of major depression and cardio-metabolic disease, as both traits are frequently comorbid and each represents a major burden to society. This study examined whether there is a genetic association between major depression and cardio-metabolic traits and if this association is stratified by age at onset for major depression. Polygenic risk scores analysis and linkage disequilibrium score regression was performed to examine whether differences in shared genetic etiology exist between depression case control status (N cases = 40,940, N controls = 67,532), earlier (N = 15,844), and later onset depression (N = 15,800) with body mass index, coronary artery disease, stroke, and type 2 diabetes in 11 data sets from the Psychiatric Gen

SUBMITTER: Hagenaars SP 

PROVIDER: S-EPMC7991693 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature