Revisiting the Relationship Between Alzheimer's Disease and Cancer With a circRNA Perspective.

ABSTRACT:

Background

Increasing evidence indicates an association between the incidence of Alzheimer's disease (AD) and cancer development. Despite advances being made by comparisons from epidemiological studies, common pathways and molecular mechanisms, little is known about the identities of the circular RNAs (circRNAs) involved in the development and progression of these two pathologies and their possible correlations. The aim of this study was to explore the circRNA relationship between AD and cancer.

Materials and methods

In this investigation, circRNAs that were significantly dysregulated in AD or associated with AD diagnosis, clinical dementia severity, and neuropathological severity, were examined in a large panel of 28 cancer types. On the basis of shared abnormal circRNAs in

SUBMITTER: Chen D 

PROVIDER: S-EPMC7991802 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature