Association Between Surgical Margins Larger Than 1 cm and Overall Survival in Patients With Merkel Cell Carcinoma.

ABSTRACT:

Importance

Current recommendations regarding the size of local excision (LE) margins for Merkel cell carcinoma (MCC) have not been well established.

Objective

To assess whether larger clinical LE margins and receipt of adjuvant radiotherapy are associated with improvements in overall survival (OS) among patients with localized MCC.

Design, setting, and participants

This large multicenter retrospective cohort study used records from the National Cancer Database to identify adult patients with localized stage I or stage II MCC who underwent LE between January 1, 2004, and December 31, 2015. Data were analyzed from August 1, 2020, to January 25, 2021.

Exposures

Local excision margin size and adjuvant radiotherapy.

Main outcomes and measures

Overall and net

SUBMITTER: Andruska N 

PROVIDER: S-EPMC7992025 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature