A computational biomarker of juvenile myoclonic epilepsy from resting-state MEG.

ABSTRACT:

Objective

For people with idiopathic generalized epilepsy, functional networks derived from their resting-state scalp electrophysiological recordings have shown an inherent higher propensity to generate seizures than those from healthy controls when assessed using the concept of brain network ictogenicity (BNI). Herein we tested whether the BNI framework is applicable to resting-state magnetoencephalography (MEG) from people with juvenile myoclonic epilepsy (JME).

Methods

The BNI framework consists in deriving a functional network from apparently normal brain activity, placing a mathematical model of ictogenicity into the network and then computing how often such network generates seizures in silico. We considered data from 26 people with JME and 26 healthy controls.

Resu

SUBMITTER: Lopes MA 

PROVIDER: S-EPMC7992031 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature