Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies.

ABSTRACT:

Background

Prospective studies of Zika virus in pregnancy have reported rates of congenital Zika syndrome and other adverse outcomes by trimester. However, Zika virus can infect and damage the fetus early in utero, but clear before delivery. The true vertical transmission rate is therefore unknown. We aimed to provide the first estimates of underlying vertical transmission rates and adverse outcomes due to congenital infection with Zika virus by trimester of exposure.

Methods

This was a Bayesian latent class analysis of data from seven prospective studies of Zika virus in pregnancy. We estimated vertical transmission rates, rates of Zika-virus-related and non-Zika-virus-related adverse outcomes, and the diagnostic sensitivity of markers of congenital infection. We allowed fo

SUBMITTER: Ades AE 

PROVIDER: S-EPMC7992034 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature