Microbiological versus Chemical Reductive Sulfidation: An Experimental and Theoretical Study.

ABSTRACT: Microbiological reductive sulfidation (RS) has rarely been documented, although it represents an efficient strategy for thiol formation. In this work, we reported on the sulfate-respiring bacterium Desulfovibrio sp.86 that has previously demonstrated RS activity toward the pesticide chlordecone. The purpose of this study was to assess its substrate versatility using a set of 28 carbonyls, to compare with chemical RS and to rationalize the observed trends using a dual experimental and theoretical approach. The chemical RS generally proceeds in two steps (S/O exchange using a sulfur donor like P₄S₁₀, reduction of the thione intermediate). Intriguingly, chlordecone was found to be converted into chlordecthiol following the first step. Hence, we designed a protocol

SUBMITTER: Della-Negra O 

PROVIDER: S-EPMC7992082 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature