Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy.

ABSTRACT: Frequency domain diffuse optical spectroscopy (FD-DOS) uses intensity modulated light to measure the absorption and reduced scattering coefficients of turbid media such as biological tissue. Some FD-DOS instruments utilize a single modulation frequency, whereas others use hundreds of frequencies. The effect of modulation frequency choice and measurement bandwidth on optical property (OP) extraction accuracy has not yet been fully characterized. We aim to assess the effect of modulation frequency selection on OP extraction error and develop a high-speed look-up table (LUT) approach for OP estimation. We first used noise-free simulations of light transport in homogeneous media to determine optimized iterative inversion model parameters and developed a new multi-frequency LUT method to increa

SUBMITTER: Applegate M 

PROVIDER: S-EPMC7992233 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature