Radiofrequency ablation alters the microstructural organization of healthy and enzymatically digested porcine mitral valves.

ABSTRACT:

Background

Myxomatous mitral valve degeneration is a common cause of mitral regurgitation and is often associated with mitral valve prolapse. With no known targets to pharmacologically treat mitral valve prolapse, surgery is often the only treatment option. Recently, radiofrequency ablation has been proposed as a percutaneous alternative to surgical resection for the reduction of mitral valve leaflet area.

Objective

Using an in vitro model of porcine mitral valve anterior leaflet enlargement following enzymatic digestion, we sought to investigate mechanisms by which radiofrequency ablation alters the geometry, microstructural organization, and mechanical properties of healthy and digested leaflets.

Methods

Paired measurements before and after ablation revealed the imp

SUBMITTER: Bender JM 

PROVIDER: S-EPMC7992362 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature