Meta-analysis and review of functional neuroimaging differences underlying adolescent vulnerability to substance use.

ABSTRACT: Adolescence is increasingly viewed as a sensitive period in the development of substance use disorders (SUDs). Neurodevelopmental 'dual-risk' theories suggest adolescent vulnerability to problematic substance use is driven by an overactive reward drive mediated by the striatum, and poor cognitive control mediated by the prefrontal cortex. To this end, there has been a growing number of neuroimaging studies examining cognitive and affective neural systems during adolescence for markers of vulnerability to problematic substance use. Here, we perform a coordinate-based meta-analysis on this emerging literature. Twenty-two task-based voxelwise fMRI studies with activation differences associated with substance use vulnerability, representative of approximately 1092 subjects, were identified thr

SUBMITTER: Tervo-Clemmens B 

PROVIDER: S-EPMC7992390 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature