TSLP Polymorphisms in Atopic Dermatitis and Atopic March in Koreans.

ABSTRACT:

Background

Atopic march (AM) is the progression from atopic dermatitis (AD) to allergic rhinitis and asthma. The development of AD is as high as 20% in children worldwide and continues to increase. AD seems to be caused by both genetic and environmental factors. Recently, polymorphisms of the thymic stromal lymphopoietin (TSLP) gene associated with allergic disorders were reported in ethnic groups from various countries.

Objective

Identification of TSLP polymorphisms in Koreans with AD or AM.

Methods

Whole-exome sequencing was performed in 20 AD and 20 AM patients.

Results

Nine single nucleotide polymorphisms (SNPs) of TSLP were detected (rs191607411, rs3806933, rs2289276, rs2289277, rs2289278, rs139817258, rs11466749, rs11466750, rs1007381

SUBMITTER: Heo WI 

PROVIDER: S-EPMC7992469 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature