Association of DOCK8, IL17RA, and KLK12 Polymorphisms with Atopic Dermatitis in Koreans.

ABSTRACT:

Background

Early-onset and severe atopic dermatitis (AD) in patients increase the probability of the development of allergic rhinitis or asthma. Treatment and prevention strategies in infants and young children with AD are targeted toward treating the symptoms, restoring skin barrier functions, and reducing the absorption of environmental allergens in an attempt to attenuate or block the onset of asthma and food allergy.

Objective

Given that the initiating events in AD remain poorly understood, identifying those at risk and implementing strategies to prevent AD is necessary.

Methods

Whole-exome sequencing (WES) was performed in a 43 control group and a disease group with 20 AD patients without atopic march (AM) and 20 with AM. Sanger sequencing was carried out to vali

SUBMITTER: Heo WI 

PROVIDER: S-EPMC7992614 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature