Puberty timing and markers of cardiovascular structure and function at 25 years: a prospective cohort study.

ABSTRACT:

Background

Whether earlier onset of puberty is associated with higher cardiovascular risk in early adulthood is not well understood. Our objective was to examine the association between puberty timing and markers of cardiovascular structure and function at age 25 years.

Methods

We conducted a prospective birth cohort study using data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Participants were born between April 1, 1991, and December 31, 1992. Exposure of interest was age at peak height velocity (aPHV), an objective and validated growth-based measure of puberty onset. Outcome measures included cardiovascular structure and function at age 25 years: carotid intima-media thickness (CIMT), left ventricular mass index (LVMI) and relative wall thickness (RW

SUBMITTER: Maher GM 

PROVIDER: S-EPMC7992788 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature