Allogeneic human neural stem cells for improved therapeutic delivery to peritoneal ovarian cancer.

ABSTRACT:

Background

Immortalized, clonal HB1.F3.CD 21 human neural stem/progenitor cells (NSCs), loaded with therapeutic cargo prior to intraperitoneal (IP) injection, have been shown to improve the delivery and efficacy of therapeutic agents in pre-clinical models of stage III ovarian cancer. In previous studies, the distribution and efficacy of the NSC-delivered cargo has been examined; however, the fate of the NSCs has not yet been explored.

Methods

To monitor NSC tropism, we used an unconventional method of quantifying endocytosed gold nanorods to overcome the weaknesses of existing cell-tracking technologies.

Results

Here, we report efficient tumor tropism of HB1.F3.CD 21 NSCs, showing that they primarily distribute to the tumor stroma surrounding individual tumor foci wi

SUBMITTER: Mooney R 

PROVIDER: S-EPMC7992793 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature