Effects of Red Blood Cell Sickling on Right Ventricular Afterload in vivo.

ABSTRACT:

Background

Hemolysis in sickle cell disease (SCD) releases cell free hemoglobin, which scavenges nitric oxide (NO), leading to pulmonary vascular vasoconstriction, increased pulmonary vascular resistance (PVR), and the development of PH. However, PVR is only one component of right ventricular (RV) afterload. Whether sickled red blood cells increase the total RV afterload, including compliance and wave reflections, is unclear.

Objective

Patients with SCD and pulmonary hypertension (PH) have a significantly increased risk of sudden death compared to patients with SCD alone. Sickled red blood cells (RBCs) are fragile and lyse easily. Here, we sought to determine the acute effects of SCD RBCs and increased cell free hemoglobin on RV afterload.

Methods

Main pulmonary arter

SUBMITTER: Schreier DA 

PROVIDER: S-EPMC7992815 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature