Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice.

ABSTRACT:

Background

Transforming growth factor beta1 (TGFB1) is a multi-functional cytokine that regulates mammary gland development and cancer progression through endocrine, paracrine and autocrine mechanisms. TGFB1 also plays roles in tumour development and progression, and its increased expression is associated with an increased breast cancer risk. Macrophages are key target cells for TGFB1 action, also playing crucial roles in tumourigenesis. However, the precise role of TGFB-regulated macrophages in the mammary gland is unclear. This study investigated the effect of attenuated TGFB signalling in macrophages on mammary gland development and mammary cancer susceptibility in mice.

Methods

A transgenic mouse model was generated, wherein a dominant negative TGFB receptor is activated

SUBMITTER: Sun X 

PROVIDER: S-EPMC7992865 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature