Identification of the potential novel biomarkers as susceptibility gene for Wilms tumor.

ABSTRACT:

Background

Wilms tumor (WT) is the most common malignant renal tumor in children. The aim of this study was to identify potential susceptibility gene of WT for better prognosis.

Methods

Weighted gene coexpression network analysis is used for the detection of clinically important biomarkers associated with WT.

Results

In the study, 59 tissue samples from National Cancer Institute were pretreated for constructing gene co-expression network, while 224 samples also downloaded from National Cancer Institute were used for hub gene validation and module preservation analysis. Three modules were found to be highly correlated with WT, and 44 top hub genes were identified in these key modules eventually. In addition, both the module preservation analysis and gene validation sho

SUBMITTER: Liu L 

PROVIDER: S-EPMC7992941 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature