Mitochondrial genotype alters the impact of rapamycin on the transcriptional response to nutrients in Drosophila.

ABSTRACT:

Background

In addition to their well characterized role in cellular energy production, new evidence has revealed the involvement of mitochondria in diverse signaling pathways that regulate a broad array of cellular functions. The mitochondrial genome (mtDNA) encodes essential components of the oxidative phosphorylation (OXPHOS) pathway whose expression must be coordinated with the components transcribed from the nuclear genome. Mitochondrial dysfunction is associated with disorders including cancer and neurodegenerative diseases, yet the role of the complex interactions between the mitochondrial and nuclear genomes are poorly understood.

Results

Using a Drosophila model in which alternative mtDNAs are present on a common nuclear background, we studied the effects of this alt

SUBMITTER: Santiago JC 

PROVIDER: S-EPMC7992956 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature