NRF2 is required for structural and metabolic maturation of human induced pluripotent stem cell-derived ardiomyocytes.

ABSTRACT:

Background

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for regenerative medicine and in drugs screening. Despite displaying key cardiomyocyte phenotypic characteristics, they more closely resemble fetal/neonatal cardiomyocytes and are still immature; these cells mainly rely on glucose as a substrate for metabolic energy, while mature cardiomyocytes mainly employ oxidative phosphorylation of fatty acids. Studies showed that the alteration of metabolism pattern from glycolysis to oxidative phosphorylation improve the maturity of hiPSC-CMs. As a transcription factor, accumulating evidences showed the important role of NRF2 in the regulation of energy metabolism, which directly regulates the expression of mitochondrial respiratory complexes

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7992990 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature